开发资源节约型和低碳型合成技术是现代化学的核心挑战之一。传统上，强C-O键、C-N键和C-F键的活化往往依赖于苛刻的反应条件和化学计量的试剂，导致大量能源消耗和化学废物产生。我们的研究致力于将电化学有机合成建立为一个可编程的平台，用于选择性键活化和分子构建。原创性贡献包括：醇类底物的电化学脱氧官能团化、胺类化合物的C-N键活化及脱氨交叉偶联，以及钴催化的脱氟C-C键形成。通过将界面电子转移与自由基化学、极性调控、过渡金属催化、牺牲阳极策略和连续流加工相结合，本研究开辟了传统热化学难以实现的反应途径。所建立的方法减少了试剂浪费，拓展了可及的化学空间，并为后期官能团化及药物相关分子的合成提供了高效路线，为更绿色的制药生产和可持续的精细化学品制造提供了具有广泛适用性的技术。
The development of resource-efficient and low-carbon synthetic technologies is a central challenge in modern chemistry. Conventional activation of strong C-O, C-N and C-F bonds often relies on forcing conditions and stoichiometric reagents, resulting in substantial energy consumption and chemical waste. Our research focuses on establishing electrochemical organic synthesis as a programmable platform for selective bond activation and molecular construction. Original contributions include electrochemical deoxygenative functionalization of alcohol-derived substrates, C-N bond activation and deaminative cross-coupling of amine-derived compounds, and cobalt-catalyzed defluorinative C-C bond formation. By integrating interfacial electron transfer with radical chemistry, polarity control, transition-metal catalysis, sacrificial-anode strategies and flow processing, this work opens reaction pathways that are difficult to access through conventional thermal chemistry. The resulting methods reduce reagent waste, expand accessible chemical space and provide efficient routes for late-stage diversification and the synthesis of medicinally relevant molecules, offering broadly applicable technologies for greener pharmaceutical production and sustainable fine-chemical manufacturing.
Selected Publication
1. Redirecting Nitroarene Electroreduction toward Nitrogen-Scaffold Synthesis, Leitao Xu*; Bowei Yuan; Zhuqian Cai; Bo Wang; Bowen Gao; Aleksandr Y. Pereverzev; Yi Zhu; Chao Qian; Jana Roithová* and Yi Wang*. DOI：10.1021/jacs.6c11800.
2. Reductive deaminative cross-coupling of alkyl bistriflimides enabled by electrocatalysis, Xiangzhang Tao; Wooseok Lee; Zhimin Xu; Hui Shu; Qing Wang; Shengyang Ni; Yi Pan; Sungwoo Hong*; Yi Wang*, Sci. Adv., 2024, 10, eads5410.
3. Electrochemical Deoxygenative Amination of Stabilized Alkyl Radicals from Activated Alcohols, Jia Xu; Yilin Liu; Qing Wang; Xiangzhang Tao; Shengyang Ni; Weigang Zhang; Lei Yu; Yi Pan; Yi Wang*, Nat. Commun., 2024, 15, 6116.
4. Electrochemical C–N bond activation for deaminative reductive coupling of Katritzky salts, Yeqing Liu; Xiangzhang Tao; Yu Mao; Xin Yuan; Jiangkai Qiu; Linyu Kong; Shengyang Ni*; Kai Guo*; Yi Wang* & Yi Pan, Nat. Commun., 2021, 12, 6745.
5. Alkyl Carbazates for Electrochemical Deoxygenative Functionalization of Heteroarenes, Yongyuan Gao; Zhengguang Wu; Lei Yu; Yi Wang* and Yi Pan, Angew. Chem. Int. Ed., 2020, 59, 10859–10863.
开发资源节约型和低碳型合成技术是现代化学的核心挑战之一。传统上，强C-O键、C-N键和C-F键的活化往往依赖于苛刻的反应条件和化学计量的试剂，导致大量能源消耗和化学废物产生。我们的研究致力于将电化学有机合成建立为一个可编程的平台，用于选择性键活化和分子构建。原创性贡献包括：醇类底物的电化学脱氧官能团化、胺类化合物的C-N键活化及脱氨交叉偶联，以及钴催化的脱氟C-C键形成。通过将界面电子转移与自由基化学、极性调控、过渡金属催化、牺牲阳极策略和连续流加工相结合，本研究开辟了传统热化学难以实现的反应途径。所建立的方法减少了试剂浪费，拓展了可及的化学空间，并为后期官能团化及药物相关分子的合成提供了高效路线，为更绿色的制药生产和可持续的精细化学品制造提供了具有广泛适用性的技术。
The development of resource-efficient and low-carbon synthetic technologies is a central challenge in modern chemistry. Conventional activation of strong C-O, C-N and C-F bonds often relies on forcing conditions and stoichiometric reagents, resulting in substantial energy consumption and chemical waste. Our research focuses on establishing electrochemical organic synthesis as a programmable platform for selective bond activation and molecular construction. Original contributions include electrochemical deoxygenative functionalization of alcohol-derived substrates, C-N bond activation and deaminative cross-coupling of amine-derived compounds, and cobalt-catalyzed defluorinative C-C bond formation. By integrating interfacial electron transfer with radical chemistry, polarity control, transition-metal catalysis, sacrificial-anode strategies and flow processing, this work opens reaction pathways that are difficult to access through conventional thermal chemistry. The resulting methods reduce reagent waste, expand accessible chemical space and provide efficient routes for late-stage diversification and the synthesis of medicinally relevant molecules, offering broadly applicable technologies for greener pharmaceutical production and sustainable fine-chemical manufacturing.
Selected Publication
1. Redirecting Nitroarene Electroreduction toward Nitrogen-Scaffold Synthesis, Leitao Xu*; Bowei Yuan; Zhuqian Cai; Bo Wang; Bowen Gao; Aleksandr Y. Pereverzev; Yi Zhu; Chao Qian; Jana Roithová* and Yi Wang*. DOI：10.1021/jacs.6c11800.
2. Reductive deaminative cross-coupling of alkyl bistriflimides enabled by electrocatalysis, Xiangzhang Tao; Wooseok Lee; Zhimin Xu; Hui Shu; Qing Wang; Shengyang Ni; Yi Pan; Sungwoo Hong*; Yi Wang*, Sci. Adv., 2024, 10, eads5410.
3. Electrochemical Deoxygenative Amination of Stabilized Alkyl Radicals from Activated Alcohols, Jia Xu; Yilin Liu; Qing Wang; Xiangzhang Tao; Shengyang Ni; Weigang Zhang; Lei Yu; Yi Pan; Yi Wang*, Nat. Commun., 2024, 15, 6116.
4. Electrochemical C–N bond activation for deaminative reductive coupling of Katritzky salts, Yeqing Liu; Xiangzhang Tao; Yu Mao; Xin Yuan; Jiangkai Qiu; Linyu Kong; Shengyang Ni*; Kai Guo*; Yi Wang* & Yi Pan, Nat. Commun., 2021, 12, 6745.
5. Alkyl Carbazates for Electrochemical Deoxygenative Functionalization of Heteroarenes, Yongyuan Gao; Zhengguang Wu; Lei Yu; Yi Wang* and Yi Pan, Angew. Chem. Int. Ed., 2020, 59, 10859–10863.